Tor atg13
WebMar 11, 2016 · In yeast, the upstream signals that regulate the induction of starvation-induced autophagy are clearly defined. The nutrient-sensing kinase Tor inhibits the … WebMar 2, 2005 · Atg13 was hyperphosphorylated in a Tor-dependent manner in rich medium conditions. This form of Atg13 has a low affinity for Atg1 (Figure 2, lane 1; Kamada et al., 2000). Rapamycin treatment, which inhibits Tor, resulted in dephosphorylation of Atg13, and dephosphorylated Atg13 showed a higher affinity for Atg1 (Figure 2, lane 3).
Tor atg13
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WebMar 18, 2013 · Autophagy-related 13 (Atg13) is a key early-acting factor in autophagy and the major locus for nutrient-dependent regulation of autophagy by Tor. The 2.3-Å resolution crystal structure of the N-terminal domain of Atg13 reveals a previously unidentified HORMA (Hop1p, Rev1p and Mad2) domain similar to that of the spindle checkpoint protein Mad2. WebDec 7, 2009 · Atg13 is phosphorylated in a Tor-dependent manner, and when isolated from cells under nutrient-rich conditions, Atg13 migrates more slowly by SDS-PAGE, suggesting …
WebAtg13 results in a similar, selective defect in autophagy in response to TOR inactivation. Atg1 physically interacts with TOR and Atg13 in vivo, and both Atg1 and Atg13 are phosphorylated in a nutrient-, TOR- and Atg1 kinase-dependent manner. In contrast to yeast, phosphorylation of Atg13 is greatest under autophagic conditions and does not ... WebMar 18, 2013 · Autophagy-related 13 (Atg13) is a key early-acting factor in autophagy and the major locus for nutrient-dependent regulation of autophagy by Tor. The 2.3-Å …
WebThe Touareg Hybrid combines a supercharged 3.0-liter V-6 gas engine with an electric motor for a combined 380 hp and 428 pounds-feet of torque. It can stay in electric mode for … WebThe protein encoded by this gene is an autophagy factor and a target of the TOR kinase signaling pathway. The encoded protein is essential for autophagosome formation and mitophagy. [provided by RefSeq, Oct 2016] Other designations. autophagy-related protein 13, ATG13 autophagy related 13 homolog. GeneRIFs: Gene References Into Functions
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jarvis george housing co-operative incWebOct 26, 2024 · Similar to S. cerevisiae, the regulatory protein TOR directly phosphorylates Atg13 in M. oryzae under normal growth conditions, which prevents its interaction with Atg1. However, when pathogenic fungi are stressed by the external environment, such as nutrient deficiency, injury, hypoxia, and reactive oxygen species (ROS) accumulation or treated ... jarvis grey companies houseWebAutophagy-related protein 13. Autophagy-related protein 13 also known as ATG13 is a protein that in humans is encoded by the KIAA0652 gene. [5] ATG13 is an autophagy factor required for phagosome formation. ATG13 is a target of the TOR kinase signaling pathway that regulates autophagy through phosphorylation of ATG13 and ULK1, and the ... jarvis guillory manvel txWebMar 1, 2014 · Inhibitory phosphorylation of Atg13 reflects the activity of TOR complex 1 (TORC1) and protein kinase A. Accordingly, monitoring the phosphorylation state of Atg13 provides a convenient way to follow early steps of autophagy induction as well as the activity of some of the upstream nutrient-sensing kinases. However, the detection of … jarvis greer cancerWebUnder nutrient-rich conditions, Atg13 is highly phosphorylated by Tor (target of rapamycin) kinase, a master regulator of nutrient signaling within the cell, and this … jarvis funeral home paden city west virginiaWebStrongest vs. Weakest. "Accelerator" ( 一方通行 アクセラレータ Akuserarēta?, lit. "One-Way Road") is the 13th episode of the Toaru Majutsu no Index anime series. It was first … jarvis greer motherWeband Tor kinases both phosphorylate Atg13 but appear to do so at distinct sites within Figure 1. A model proposing that the pKA and tor pathways independently control autophagy via … jarvis gann taxpayers association