WebSep 24, 2012 · CytR is a transcription regulator from the LacI family, present in some gamma-proteobacteria including Escherichia coli and known not only for its cellular role, control of transport and utilization of nucleosides, … WebApr 15, 2000 · We will first present an overview of the transcription factors, emphasizing their structural and functional properties, such as their DNA-binding motif and their regulatory roles. Then we will describe the regulators distributed amongst their evolutionary families and discuss some functional correlations.
Deciphering the enigma of missing DNA binding domain of LacI …
The lac repressor (LacI) operates by a helix-turn-helix motif in its DNA-binding domain, binding base-specifically to the major groove of the operator region of the lac operon, with base contacts also made by residues of symmetry-related alpha helices, the "hinge" helices, which bind deeply in the minor groove. This bound repressor can reduce transcription of the Lac proteins by occluding the RNA polymerase binding site or by prompting DNA looping. When lactose is present, allolacto… WebDec 15, 2012 · Effects of two putative LacI-family transcriptional regulators, SCO4158 and SCO7554, on antibiotic pigment production of Streptomyces coelicolor and Streptomyces … the secret garden burnett
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WebNov 30, 2024 · In numerous studies to crystallize the apo form of the LacI family transcription factor, the N-terminal domain (NTD), which functions as a DNA-binding … WebDec 14, 2012 · Structural homology searches revealed that this domain shows the strongest similarity to the periplasmic-binding protein (PBP) domains of the LacI/GalR family of transcription regulator . In particular, the XylR N-terminal domain is the most similar to the PBP domain of the Purine Repressor, PurR (27, 28 Supplementary Figure S1). WebJan 10, 2024 · A more recent study showed that the mutant of slyA, which encodes a SlyA/MarR family transcription regulator, is significantly decreased in zeamine production, biofilm formation and pathogenicity ... the secret garden by zeekri review