Klf4 function

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August undefined, 2024

WebFeb 2, 2024 · Here, we show that endothelial KLF2 and KLF4 control a large segment of the endothelial transcriptome, thereby affecting virtually all key endothelial functions. Inducible endothelial-specific deletion of Klf2 and/or Klf4 reveals that a single allele of either gene is sufficient for survival, but absence of both (EC-DKO) results in acute death ... WebSep 10, 2013 · Although the present studies have focused on phenotypic modulation of SMCs and KLF4 during aneurysm formation, KLF4 also may have broad significance for the overall aneurysm phenotype given that KLF4 is already known to play key roles in mediating cellular function and proliferation in other cell types. 16,23,39,44 However, further studies …

KLF4 acts as a tumor suppressor in human B-cells and …

Webof KLF4 has been reported in various tumors, and resto-ration of KLF4 expression can induce growth arrest in colon cancer cells and apoptosis in bladder and gastric cancer cells and leukemia cells.10–14 Furthermore, accu-mulating clinical evidence suggests that KLF4 functions as a tumor suppressor, and studies have found genetic WebUsing next-generation sequencing data, we identified the binding of PS-induced Krüppel-like factor 4 (KLF4), which functions as a pioneer transcription factor, binding to the GCKR promoter to change the chromatin structure for transactivation of GCKR. At the posttranslational level, PS-activated AMP-activated protein kinase (AMPK ... happiness in the bible

KLF4 transcription factor in tumorigenesis Cell Death Discovery

WebMar 17, 2024 · However, in immune cells from older mice, KLF4 levels did not change throughout the day. In the immune cells from young mice, KLF4 controls the normal daily … WebMay 5, 2024 · The Krüppel-like factor 4 (KLF4; also called gut-enriched Krüppel-like factor or GKLF) was first isolated by Shields et al., from a NIH3T3 cDNA library (Shields et al., … WebMar 2, 2024 · KLF4 is a transcription factor that plays significant tumor-suppressive roles in the pathogenesis and progression of HCC, such as promoting tumor differentiation, suppressing epithelial-mesenchymal transition, and restraining tumor growth and metastasis ( Sun et al., 2024 ). chain reaction channel

Klf4 Kruppel-like factor 4 (gut) [ (house mouse)] - National Center …

BASIC—LIVER, PANCREAS, AND BILIARY TRACT

WebKLF4 belongs to the Kruppel-like factor (KLF) family, a group of conserved zinc finger TFs that regulates essential biological processes such as proliferation and development. Reflecting pioneer factor activity, KLF4 uses two out of its three zinc fingers to target a GC-rich hexameric motif enriched within nucleosomal targets22 ( Fig. 7.2 C). WebMar 21, 2024 · KLF4 (KLF Transcription Factor 4) is a Protein Coding gene. Diseases associated with KLF4 include Epilepsy, Idiopathic Generalized 15 and Familial Adenomatous Polyposis . Among its related pathways are … happiness in the workplace statisticsWebKlf4 inhibits proliferation through activation of p21Cip1/Waf1, and direct suppression of cyclin D1 and cyclin B1 gene expression. Both Klf4 & Klf5 proteins act on the Klf4 … chain reaction challenge game

"WebMay 28, 2024 · En el año 2006 fueron generadas las células madre plu- ripotenciales inducidas (IPs). Las IPs son células adultas diferenciadas, pero tras la inducción con la inserción de 4 genes en su núcleo (Oct4, Sox2, c-Myc, y Klf4), se comportan como células embrionarias con plasticidad histogenética. " - Klf4 function

Klf4 function

Klf4, Klf2, and Zfp148 activate autophagy-related genes in smooth ...

WebSep 23, 2024 · The architectural function of KLF4 is further supported by the observations that KLF4 depletion abrogates long-range chromatin contacts at specific genomic loci, … WebBackground & aims: Krüppel-like factor 4 (KLF4) is a transcription factor associated with tumor suppression and oncogenesis. KLF4 suppresses pancreatic tumorigenesis by unknown mechanisms; we investigated alterations that might affect KLF4 function and lead to tumor formation.

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WebSep 30, 2015 · KLF4 is an important regulator of cell-fate decision, including DNA damage response and apoptosis. We identify a novel interplay between protein modifications in regulating KLF4 function. WebThere is evidence to suggest that transcription factor KLF4 plays a crucial role in the progression of breast carcinoma, 14 squamous cell carcinoma, 15 lung cancer, 16 and …

WebKLF4 T Cell In Vitro Human Umbilical Vein Endothelial Cell Endothelial Nitric Oxide Synthase Mitogen Activated Protein Kinase 7 View all Topics Add to Mendeley Set alert About this page Genetics of Cardiovascular Disease Peter Novodvorsky, Timothy J.A. Chico, inProgress in Molecular Biology and Translational Science, 2014 6Summary WebDec 3, 2024 · Both KLF4 and Sp5 have been shown to regulate naive pluripotency in part through the transcriptional regulation of Nanog, whose downregulation marks the exit of ESCs from the naive state into a state that is primed for lineage specification 29 – 31. Interestingly, we observed downregulation of both Nanog and Klf4 in I-BRD9-treated ESCs …

WebKLF4 is demonstrated with the function of re-activating the CD8 T cell by stimulating c-Jun generation in the immune response against cancer [37]. In addition to the functions mentioned earlier, KLF4 has been found to strongly increase the expression of the MMP gene in chondrocytes, which is beneficial for cartilage development [38] . WebFeb 10, 2009 · KLF4 glutamylation state plays a critical role in the regulation of its function in cell reprogramming, pluripotency maintenance and embryogenesis. By similarity …

WebNov 12, 2015 · The function of KLF4 in the kidney is still not well understood. In this review, we highlight recent findings on how KLF4 regulates renal fibrosis, with the aim of evaluating the potential of KLF4 as a novel therapeutic target for renal fibrosis. The biological characteristics of KLF4.

WebConclusions: KLF4 may function as a tumor suppressor gene in urothelial cancer since down-regulation of KLF4 by promoter hypermethylation would promote cancer progression. In addition, decreased expression of KLF4 or its promoter hypermethylation may have predictive value for early recurrence in patients with nonmuscle invasive bladder cancer. chain reaction chemistry chain reaction code promoWebMar 19, 2010 · Transcription factor Kruppel-like factor 4 (Klf4) is essential for somatic cell reprogramming. In addition, Klf4 seems to play a redundant role along with other Klf family proteins in embryonic stem (ES) cell self-renewal. However, how Klf4 regulates ES cell self-renewal and somatic cell reprogramming is still poorly understood. Here we report that … happiness in transitWebAug 16, 2024 · Here, we studied the function of KLF4 in two complementary model systems of B-cell malignancies to decipher its role in oncogenesis and tumor dependency, respectively. We found a clear tumor suppressor function of KLF4 during EBV-mediated B-cell transformation into lymphoblastoid cells. In established tumors from patients with … happiness in the workplace quotesWebAug 28, 2013 · General functions of KLF4 3.1. Inhibition of cell proliferation KLF4 is known to induce growth arrest, inhibiting cell proliferation by regulating the expression of key cell … happiness inventoriesWebJan 3, 2024 · Importantly, KLF4 overexpression boosted activation of the IL-6 promoter, whereas KLF4 knockdown suppressed activation of the IL-6 promoter , implicating that KLF4 functions as a positive regulator of IL-6 gene transcription in GMCs exposed to sublytic C5b-9. KLF4 Activates IL-6 Promoter by Binding to Proximal Binding Site happiness inventoryWebKLF4 has pleiotropic functions in EC biology. It is widely considered a vascular protective factor due to its ability to activate specific transcriptional programs with anti-inflammatory, anticoagulant, and antioxidant roles in the endothelium (Hamik et al, 2007; Zhou et al, 2012; Shatat et al, 2014). chainreaction cycle