Fbw7a
WebPreclinical Development Triggering Fbw7-Mediated Proteasomal Degradation of c-Myc by Oridonin Induces Cell Growth Inhibition and Apoptosis Hui-Lin Huang, Heng-You Weng, Lu-Qin Wang, Chun-Hong Yu, Qiao-Juan Huang, Pan-Pan Zhao, WebDownload scientific diagram BLM Increases Fbw7a-Mediated K48-and K63-Linked c-Jun Ubiquitylation (A) Fbw7a-mediated in vitro ubiquitylation of c-Jun occur via mixed …
Fbw7a
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WebCommon Uses of AAV. AAV is commonly used in optogenetics experiments. These viruses are preferred over lentiviruses because they remain primarily episomal, while lentiviruses … AAV Plasmids. This table contains a general list of plasmids that are useful in … *AAVrg = retrograde serotype, produced with the AAV retro helper plasmid from … We provide high quality AAV preps from select plasmids in the repository. … Collection of adenovirus shuttle vectors and strains. Adenoviruses are a class of … WebApr 17, 2024 · The mechanistic study showed that Smurf1 interacts with SREBP-1c and protects SREBP-1c from ubiquitination and degradation by preventing the binding of SREBP-1c to its ubiquitin E3 ligase Fbw7a. Thus, our study presented an E3 ligase catalytic activity-independent function of Smurf1 in the fatty liver development.
WebUSP28 Cell proliferation MYC FBW7A 4 DNA damage response TP53BP1, claspin Unknown 3 USP44 Cell cycle regulation CDC20 Unknown 3 CYLD NF-κB signalling TRAF2, TRAF6 NEMO (IKBKG) 4 Cell proliferation BCL3 Unknown 4 UCHL1 Ubiquitin processing Ubiquitin precursors Unknown 1 UCHL5 (UCH37) Proteasomal degradation NFRKB … Webtranscripts (Fbw7a, b,andg), which have distinct subcellular localizations: Fbw7a localizes to the nucleus, whereas Fbw7b and Fbw7g localize to cytoplasm and nucleolus, …
WebIn vitro c-Jun ubiquitylation reactions were carried out with non-radiolabeled in vitro transcribed and translated Fbw7a alone or Fbw7a in the presence of a range of …
Webkeywords = "c-Myc, CDK4, cell proliferation, FBW7a, gain of function, GOF, p53-R249S, phosphorylation, PIN1, ribosomal biogenesis, transcription", author = "Peng Liao and Zeng, {Shelya X.} and Xiang Zhou and Tianjian Chen and Fen Zhou and Bo Cao and Jung, {Ji Hoon} and {Del Sal}, Giannino and Shiwen Luo and Hua Lu",
WebFeb 12, 2009 · B, Fbw7a is a ubiquitin ligase that mono-ubiquitinates SRC-3 on serines 723 and 786 to superactivate SRC-3 and direct it preferentially to certain transcription factors, such as estrogen receptor (ER) and androgen receptor (AR). C, During each subsequent round of transcription, Fbw7a adds one more ubiquitin/round to the two sites. emotion works schoolWebApr 17, 2024 · The mechanistic study showed that Smurf1 interacts with SREBP-1c and protects SREBP-1c from ubiquitination and degradation by preventing the binding of … dr andrew chenWebApr 1, 2024 · Gain-of-function (GOF), the most malicious oncogenic activity of a cancer-promoting protein, is well illustrated to three hotspot p53 mutations at R248, R175, and … dr andrew chema akronWebDownload scientific diagram BLM is ubiquitylated by Fbw7α. (a–c) Degradation of BLM by Fbw7 depends on its N-terminal region, F-box and WD40 domain. U2OS cells were transfected with (a) Flag ... emotion work und emotional laborWebFBW7 Antibody (A301-720A) in WB. Detection of human FBW7 by western blot. Samples: Whole cell lysate (25 µg) from My-La CD4+, HeLa, NCI-H1975, SU-DHL-1, and VLN3G2 … dr andrew chen lodi caWebAug 29, 2024 · S2 Fig: Characterization of Fbw7 antibodies.A. Immunoprecipitation (IP) of xFbw7α, β and γ isoforms. xFbw7 isoforms were translated in vitro in the presence of [35 S]-methionine and immunoprecipitated with specific anti-Fbw7 antibodies for phosphorimaging and for immunoblotting analysis with anti-Fbw7 antibodies. (i) and (s) designate the … dr andrew chenelle northwestern medicineWebApr 17, 2024 · Fbw7a is known as the major ubiquitin E3 ligase for nuclear SREBP-1c (nSREBP-1c) to promote its ubiquitination and degradation. 8 mTORC2 also induces … emotion work with children