WebApr 10, 2024 · This is evident due to the impairment of autolysosomal degradation. On the other hand, glycyrrhizin treatment induces p62 degradation at 4 h and 18 h. To validate …
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WebApr 3, 2024 · By contrast, restoring autolysosomal function with metformin or rapamycin represses CCF-activated cGAS-STING-NF-κB-SASP axis by promoting autolysosome-mediated CCF degradation. SASP is a common hallmark of different types of senescence; however, the signaling governing its production remains unknown. WebApr 14, 2024 · To monitor autophagosome and autolysosome formation as well as autolysosomal targeting of E. coli, RFP-GFP-mLC3 RAW264.7 MΦ were seeded on coverslips and infected with E. coli HB101 or sCFP3A-E. coli HB101 and subjected to gentamicin-protection assays as described above. 2 h post infection, cells were fixed … bran flake cookie recipe
Lysosome biology in autophagy Cell Discovery - Nature
WebChronic or acute Dyn2 inhibition combined with nutrient deprivation stimulated the excessive tubulation of these autolysosomal compartments. Importantly, Dyn2 associated with these tubules along their length, and the tubules vesiculated and fragmented in the presence of functional Dyn2. These findings provide new evidence for the participation ... WebApr 10, 2024 · Here, we demonstrate that lipid-protein particle release by autolysosome exocytosis protects neurons from ferroptosis, a form of cell death driven by lipid … WebOct 21, 2013 · Dyn2 associates with autolysosomal tubules. (A and B) Subcellular density gradient fractionation of Hep3B hepatocytes starved for 2 h in HBSS and treated with 40 µM Dynasore, to induce tubule formation, as in Fig. 5. Cells were lysed (WCL), and the post-nuclear supernatant (PNS) was pelleted by centrifugation to produce a crude lysosomal ... bran flakes 5000 twitter